Seems like if your a Windows or Mac user. The exploits are so aggressive they lock up or even bypass the sandbox. I don't know how they mastered that. Sandboxie has a bug where you can do a buffer overflow and another where you can somewhat run executable code. I wrote an exploit that shuts down the computer and it bypassed Comodo's sandbox and Koisk program one time. Bypassing UAC with an FTP server is even easier. All you have to do is alter the executable or make it a little differently and it will modify files on the filesystem. Deepfreeze is also good. But some people forget to sandbox and end up infecting their computer. Some people don't know what software is safe for their OS. That's why I use Linux and its trusted repository. Repositories and true permissions (apparmor/selinux) make the better out of an os. I also have an offline Linux machine. If there's still exploits to DOS and evade sandboxes then why not use Linux. I reccomend ordering Deepfreeze as a WIndows user. You can also just go online on a Linux Live CD.
They've got the Live CD's with scripts disabled by default to be sure your safe.