You'll have to 'tighten' your browser to keep these jerks out in the first place.
Parasite Invasion & System Hostage counter measures.
There is, unfortunately, no blanket "2 click-fix" everyone would love.
Malwarebytes is a nice place to begin the cleanup, continue using it.
http://www.majorgeeks.com/Malwarebytes_Anti-Malware_d5756.html
Tsunami's of money hungry advertising schemes are making browse sessions unbearable. Don't let these parasites into your system in the first place! Proactive defensive measures help stop these guys on your doorstep and keep 'em out. The following tips help, but methods (vectors) constantly change.*
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FIREFOX: Tools> Options> Privacy: Check 'Accept Cookies from sites'
& Un-Check 'Accept 3rd Party cookies'
With these add-on's:
♦♦♦"NoScript" for Firefox will stop a lot of this adware/spyware & hijackers; and is THE single most important thing you can do to prevent most script based malware♦♦♦
https://addons.mozilla.org/en-US/firefox/addon/722
With "NS" running, down on the far right corner is a blue 'S' with a red line through it: right click that> tick 'forbid (whatever)' &/or mark as 'untrusted'.
(Ticking all may reduce interactive behavior; enable just enough to get what's necessary to view the page, on a 'temporarily allow' basis)
Flashblock: https://addons.mozilla.org/en-US/firefox/addon/433
Adblock Plus works pretty good too: https://addons.mozilla.org/en-US/firefox/addon/1865 (make sure to utilize the 'Subscriptions' from ABP 'Preferences' tab & look in ABP > Preferences> Filters> Add filter subscription> "View All Subscriptions" link @ top of window> (on the new window, select those which you'd like to add)> follow prompts.
The list is long...look for any that will help your browse sessions be 'cleaner'.
*Fresh exploit: "Super Cookie" threat (or Persistent 3rd party cookie); https://addons.mozilla.org/en-US/firefox/addon/6623
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INTERNET EXPLORER: Tools> Internet Options> Privacy> Advanced:
here check 'Override automatic....'; 'Allow session cookies'; 'Allow 1st party cookies' & 'Block 3rd Party Cookies'.
Using IE (all flavors) and allowing "active scripting" is the single biggest mistake people make. "Drive by installs", "Opacity based attacks", and many other malware problems arise from this feature alone.
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Rouge malware and escalating server based spyware are becoming indistinguishable & may cause system misbehavior .
Requires "Opt Out" on EVERY browser on EVERY machine.
Google here: http://www.google.com/privacy_ads.html
Yahoo here: http://info.yahoo.com/relevantads/
Turn off 'spell check' may help, as this sends keystrokes back to the server also, which may be used to 'target' advertising.
When installing ANY new application, check the EULA or TOS for 'Toolbars' and/or other crud they try to slip past ya'.
MS Windows default configuration has LAN Messenger enabled, used to distribute spam ads NOT controlled by normal (described above) methods. See GRC's "Shoot the Messenger" page for how it works and how to fix it.
http://www.grc.com/stm/shootthemessenger.htm
Good luck. ;)