1. Download and run firefox to protect your from future spyware attacks and pop ups which are coming in through internet explorer (Trojan downloaders, win32 ) .Then update your windows through firefox
Browser attacks aren't easy to spot because they piggyback on legitimate traffic that doesn't exhibit many obvious warning signs
http://securitynewsfromthenet.blogspot.com/2007/05/spyware-fighter-essentials.html
2. Run the vundo and combo fix http://securitynewsfromthenet.blogspot.com/2007/05/vundofix-and-combo-fix.html
3. Run Malwarebytes Anti-Malware
http://securitynewsfromthenet.blogspot.com/2008/03/malwarebytes-anti-malware-105.html
4. Run the anti spyware remove programs spybot http://securitynewsfromthenet.blogspot.com/2007/03/spybot-search-and-destroy-spyware-and.html and superantispyware http://securitynewsfromthenet.blogspot.com/2007/04/superantispyware-home-edition-free.html to get rid of the nasties
5. Run a complete scan with free curing utility Dr.Web CureIt!
http://www.freedrweb.com/
The best protection for your computer is a 3-tiered approach: anti-spyware software, anti-virus software, and a firewall(ZoneAlarm Free 7.0.462.0)
http://www.lavasoft.com/support/spywareeducationcenter/protect_yourself.php