How about doing a full set of housekeeping including anti spyware.
As you will appreciate there are many reasons why your computer is running slow:
I have listed the most obvious, some of which you may have already tried but for completeness they are mentioned here.
First of all make sure you do not have any malware in the form of viruses or spyware. Run your anti virus and anti spyware programs in order to clear out any beasts.
If you do not have any protection these are exceptional and available for free:
Anti virus I suggest:
http://www.avast.com/eng/avast_4_home.html
Anti spyware I suggest:
http://www.superantispyware.com/
Remove junk & temporary Internet files by running Ccleaner – free for download from:
http://filehippo.com/download_ccleaner/
Your hard disk(s) may be fragmented. Windows has a built in defragmentation program but you can download a third party program for free:
http://www.auslogics.com/en/software
Your registry may be cluttered or corrupt. Ccleaner mentioned above also has a registry cleaner but how about downloading another very good free registry cleaner:
http://www.eusing.com
You may have too many programs kicking off at start up. These free downloads allow you to control what applications run at start up:
http://www.glarysoft.com/quick-startup
http://www.mlin.net/StartupCPL.shtml
Your hard disk may be getting full. You need at least 15% of free space for it to operate efficiently. Go to Control Panel > Add/Remove Programs & remove any applications you no longer use. How about removing all those pictures & music that is filling up your hard drive?
Finally, after you have done all the above may need to upgrade your RAM. So that you get the right type of RAM for your system do a free scan at Crucial to determine your RAM.
http://www.crucial.com/ for USA
http://www.crucial.com/uk/ for UK
Good luck with your quest and I hope these suggestions improve your system.
wdw